Defective in V(D)J recombination and has no CD3 + or T cell receptor alpha/beta positive cells.Produces no mature T or B cells ( Mombaerts et al.Older mice can become 'leaky,' producing small numbers of mature T and B cells.Most mice are devoid of immunoglobulins.Normal antigen presentation, myeloid development, and NK cell functions.Deficient in mature T and B cells ( Nonoyama et al.Part of our unique Genetic Stability Program.Often develops thymic lymphomas by eight and a half months.Insulitis - and diabetes-free throughout life.Accepts allogeneic and xenogeneic grafts very efficiently and has been used successfully to transplant a variety of normal and malignant human cells and tissues, including isolates from hematopoietic cancers.NOD genetic background results in reduced NK cell activity, impaired complement pathway, and least “leakiness” of residual T and B cells of any scid strain.Thymus, lymph node, and spleen virtually devoid of lymphocytes.Commonly called “NOD scid” ( Shultz et al.Significant engraftment of patient-derived AML samples.The expression of several transgenic human cytokines supports higher levels of human myeloid cell expansion.Cg-Prkd scidIl2rg tm1WjlTg(CMV-I元,CSF2,KITLG)1Eav/MloySzJ/ (013062) Engrafts human PBMC without irradiation.Commonly known as 'NRG' or 'NOD Rag gamma” ( Pearson et al.Capable of maintaining a human tumor microenvironment after engraftment.Resistant to lymphoma, allowing for long-term experiments.Deficient in signaling of multiple cytokines (IL2, IL4, IL7, IL9, IL15 and IL21), resulting in significantly improved engraftment of human tissues, hematopoietic stem cells, and peripheral blood mononuclear cells.Lacks mature T, B, and functional NK cells.Severe defects in innate and adaptive immunity.Commonly known as “NSG™” or “NOD scid gamma” ( Shultz et al.The most powerful immunodeficient model that has changed the face of oncology, stem cell and infectious disease research. Not suitable for primary cell transplantation.Little engraftment of hematopoietic cancer cells.Poor host for primary cell transplantation.Uniform genetics improve reproducibility.Hairless phenotype enhances assessment of tumor growth.Engraftment of human & mouse tumor cell lines.Common B6 inbred background simplifies creation of compound immunodeficient mutants.MHC haplotype (H2b) allows adoptive transfer from B6 donors.Engrafts hematopoietic cancer cell lines, some primary cells.Common BALB/cBy inbred background simplifies creation of compound immunodeficient mutants.MHC haplotype (H2d) allows adoptive transfer from BALB/c donors.Develops thymic lymphomas by 8-9 months, best used in short term experiments.Compromised human stem cell regeneration.Requires higher dose of irradiation to obtain human HSC engraftment.No thymic lymphomas, can be used for long & short-term experiments.Xenotransplantation of some human tumors.Engrafts hematopoietic cancer cell lines.Adoptive transfer recipient for study of autoimmune type 1 diabetes.Increased efficiency of engrafting human acute myeloid leukemia (AML).Enhances human myelopoiesis and terminal differentiation.Increased CD4+ FoxP3+ regulatory T cell population.Engrafts a wide range of solid and hematological cancers.Engrafts human PBMC without irradiation similar to NSG.Long-term multilineage hematopoeitic stem cell repopulation similar to NSG mice.Xenotransplantation of human tissues, cells & tumors.Supports engraftment of human peripheral blood & bone marrow.NSGS, NOD scid gamma Il3- GM-SF (NSG-SGM3)

What is nod scid